This will increase the likelihood that the active substance will enter the target tissues and cells. Research has also shown that more than one substance can be loaded into a liposome to make them work synergistically. When an active substance is encapsulated in a liposome, it can be protected from rapid degradation and elimination in the body. The substance is therefore able to circulate inside the body for a longer period of time.
While the administration of liposomal medicines into the bloodstream can be a very clear and direct way to target diseased sites in the body, oral administration is often preferable as a less invasive administration route.There are many different ways to administer a liposomal form of an active substance, for instance by intravenous infusion, local injection, inhalation but also by simple oral intake. A great deal of research effort has been undertaken to engineer liposomes that pass through the stomach and intestine in an intact form, showing that in some cases the biological availability of orally administered active substances can indeed be enhanced The disadvantage of the oral route is that the liposomes have to pass through the stomach and intestine, which form a relatively hostile environment affecting the stability of liposomal products.
They are essentially nontoxic and biologically degradable.Liposomes are usually made of naturally-derived starting materials. Drug delivery selectively at diseased sites in the body increases the local concentration of the drug improving its pharmacologic effect. It has also been demonstrated that the liposomal encapsulation of a drug can significantly reduce its toxicity by the tendency of liposomes to avoid healthy organs and protect these from exposure to the encapsulated drug They have the unique ability to hold active substances – including medicines and supplements – both in their aqueous interior as well as their lipid bilayer. This makes liposomes attractive as drug delivery systems.
Protection Through Encapsulation
This effect has been attributed to that liposomes – harnessing their ability to encapsulate and transport active ingredients – can increase the bioavailability and target delivery of these ingredients in the body. The liver breaks down the active substance before it has the chance to reach the target cells. Liposomal encapsulation can help prevent this lossliposomal redirection of the actives after uptake, protecting the active substance from rapid clearance. Many active substances that are administered in the traditional manner are simply lost because after absorption they are led straight to the liver (the ‘hepatic portal system’).
Another study has shown that the intravenous administration of liposomal vitamin C leads to the highest rise in vitamin C levels in the blood. Especially lipophilic active substances that have low solubility in water, show poor absorption and thus inferior efficacy. It has been shown that lipid formulations can significantly improve the intestinal uptake of such difficult-to-formulate lipophilic actives The oral administration of liposomal vitamin C leads to slightly lower blood levels of vitamin C, but even these are still much higher than after the oral administration of non-liposomal vitamin C. However, even if intact passage through the stomach and intestine is not achieved, liposome products such as liposome vitamin supplements can be of great benefit.